Physical Examination • A testicular mass that can be felt, particularly a painless mass or one that does not completely clear within two weeks of antibiotic therapy, requires further tests. Some doctors now feel that all masses should be investigated by ultrasound . • Enlarged lymph nodes in the abdomen and neck. Blood and Other Tests • Blood tests for markers such as LDH, AFP and HCG. • Blood counts, biochemical screening profile, serum magnesium and urine collection for a creatinine clearance to evaluate kidney function. • If bleomycin is to be used, lung function tests are performed as a baseline for future comparisons before additional treatment (bleomycin can cause lung scarring). • Analysis of sperm and so-called sperm banking should be considered in most patients, since treatment can result in infertility. This might be the result of chemotherapy-induced toxicity or by loss of ejaculation if the surgical removal of lymph nodes requires cutting the nerves that control this function.